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Conserved Structural Mechanisms for Autoinhibition in IpaH Ubiquitin Ligases
The IpaH family of novel E3 ligase (NEL) enzymes occur in a variety of pathogenic and commensal bacteria that interact with eukaryotic hosts. We demonstrate that the leucine-rich repeat (LRR) substrate recognition domains of different IpaH enzymes autoinhibit the enzymatic activity of the adjacent c...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3249077/ https://ncbi.nlm.nih.gov/pubmed/22065585 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.316265 |
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