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3-Formylchromone Interacts with Cysteine 38 in p65 Protein and with Cysteine 179 in IκBα Kinase, Leading to Down-regulation of Nuclear Factor-κB (NF-κB)-regulated Gene Products and Sensitization of Tumor Cells

3-Formylchromone (3-FC) has been associated with anticancer potential through a mechanism yet to be elucidated. Because of the critical role of NF-κB in tumorigenesis, we investigated the effect of this agent on the NF-κB activation pathway. Whether activated by inflammatory agents (such as TNF-α an...

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Detalhes bibliográficos
Main Authors: Yadav, Vivek R., Prasad, Sahdeo, Gupta, Subash C., Sung, Bokyung, Phatak, Sharangdhar S., Zhang, Shuxing, Aggarwal, Bharat B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3249075/
https://ncbi.nlm.nih.gov/pubmed/22065587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.274613
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