Orexin neurons as conditional glucosensors: paradoxical regulation of sugar sensing by intracellular fuels

ABSTRACT: Central orexin/hypocretin neurons promote wakefulness, feeding and reward-seeking, and control blood glucose levels by regulating sympathetic outflow to the periphery. Glucose itself directly suppresses the electrical activity and cytosolic calcium levels of orexin cells. Recentin vitrostu...

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Bibliographic Details
Main Authors: Venner, Anne, Karnani, Mahesh M, Gonzalez, J Antonio, Jensen, Lise T, Fugger, Lars, Burdakov, Denis
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2011
Subjects:
Neuroscience: Behavioural/Systems/Cognitive
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3249044/
https://ncbi.nlm.nih.gov/pubmed/22005675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2011.217000
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