ATM germline heterozygosity does not play a role in chronic lymphocytic leukemia initiation but influences rapid disease progression through loss of the remaining ATM allele

Ataxia telangiectasia patients, with constitutional bi-allelic ATM mutations, have a marked risk of lymphoid tumors and ATM mutation carriers have a smaller risk of cancer. Sporadic ATM mutations occur in 10–20% of chronic lymphocytic leukemia and are often associated with chromosome 11q deletions w...

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Main Authors: Skowronska, Anna, Austen, Belinda, Powell, Judith E., Weston, Victoria, Oscier, David G., Dyer, Martin J.S., Matutes, Estella, Pratt, Guy, Fegan, Christopher, Moss, Paul, Taylor, Malcolm A., Stankovic, Tatjana
Format: Artigo
Sprog:Inglês
Udgivet: Ferrata Storti Foundation 2012
Fag:
Brief Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248944/
https://ncbi.nlm.nih.gov/pubmed/21933854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2011.048827
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