Tolerability of Breast Radiotherapy Among Carriers of ATM Germline Variants

ATM, a gene that controls repair of DNA double-strand breaks, confers an excess lifetime risk of breast cancer among carriers of germline pathogenic variants (PV). ATM PV homozygotes are particularly sensitive to DNA damage caused by ionizing radiation. Consequently, there is concern that adjuvant r...

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Dettagli Bibliografici
Pubblicato in:JCO Precis Oncol
Autori principali: Modlin, Leslie A., Flynn, Jessica, Zhang, Zhigang, Cahlon, Oren, Mueller, Boris, Khan, Atif J., Gillespie, Erin F., McCormick, Beryl, Stadler, Zsofia K., Robson, Mark E., Powell, Simon N., Braunstein, Lior Z.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Clinical Oncology 2021
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ORIGINAL REPORTS
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8232182/
https://ncbi.nlm.nih.gov/pubmed/34250389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.20.00334
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