Tolerability of Breast Radiotherapy Among Carriers of ATM Germline Variants

ATM, a gene that controls repair of DNA double-strand breaks, confers an excess lifetime risk of breast cancer among carriers of germline pathogenic variants (PV). ATM PV homozygotes are particularly sensitive to DNA damage caused by ionizing radiation. Consequently, there is concern that adjuvant r...

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書誌詳細
出版年:JCO Precis Oncol
主要な著者: Modlin, Leslie A., Flynn, Jessica, Zhang, Zhigang, Cahlon, Oren, Mueller, Boris, Khan, Atif J., Gillespie, Erin F., McCormick, Beryl, Stadler, Zsofia K., Robson, Mark E., Powell, Simon N., Braunstein, Lior Z.
フォーマット: Artigo
言語:Inglês
出版事項: American Society of Clinical Oncology 2021
主題:
ORIGINAL REPORTS
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC8232182/
https://ncbi.nlm.nih.gov/pubmed/34250389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.20.00334
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