Tolerability of Breast Radiotherapy Among Carriers of ATM Germline Variants

ATM, a gene that controls repair of DNA double-strand breaks, confers an excess lifetime risk of breast cancer among carriers of germline pathogenic variants (PV). ATM PV homozygotes are particularly sensitive to DNA damage caused by ionizing radiation. Consequently, there is concern that adjuvant r...

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Detalhes bibliográficos
Publicado no:JCO Precis Oncol
Main Authors: Modlin, Leslie A., Flynn, Jessica, Zhang, Zhigang, Cahlon, Oren, Mueller, Boris, Khan, Atif J., Gillespie, Erin F., McCormick, Beryl, Stadler, Zsofia K., Robson, Mark E., Powell, Simon N., Braunstein, Lior Z.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2021
Assuntos:
ORIGINAL REPORTS
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8232182/
https://ncbi.nlm.nih.gov/pubmed/34250389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.20.00334
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