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Opening of Aryl-Substituted Epoxides to form Quaternary Stereogenic Centers: Synthesis of (−)-Mesembrine

Cycloalkanones are easily converted into aryl-substituted cyclic alkenes by the addition of an aryl Grignard reagent followed by dehydration. These alkenes are good substrates for asymmetric epoxidation. We have found that the addition of allylic and benzylic Grignard reagents can occur preferential...

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Detalhes bibliográficos
Main Authors: Taber, Douglass F., He, Yigang
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248819/
https://ncbi.nlm.nih.gov/pubmed/16149803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo0511039
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