T cell receptor cross-reactivity directed by antigen-dependent tuning of peptide-MHC molecular flexibility

Tell mediated immunity requires T cell receptor (TCR) cross-reactivity, the mechanisms behind which remain incompletely elucidated. The αβ TCR A6 recognizes both the Tax (LLFGYPVYV) and Tel1p (MLWGYLQYV) peptides presented by the human class I MHC molecule HLA-A2. Here we found that although the two...

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Autores principales: Borbulevych, Oleg Y., Piepenbrink, Kurt H., Gloor, Brian E., Scott, Daniel R., Sommese, Ruth F., Cole, David K., Sewell, Andrew K., Baker, Brian M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248800/
https://ncbi.nlm.nih.gov/pubmed/20064447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2009.11.003
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