Fluorine substitutions in an antigenic peptide selectively modulate T cell receptor binding in a minimally perturbing manner

T cell receptor (TCR) recognition of antigenic peptides bound and presented by major histocompatibility complex (MHC) molecules forms the basis of the cellular immune response to pathogens and cancer. TCRs bind peptide/MHC molecules weakly and with fast kinetics, features which have hindered detaile...

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Detalhes bibliográficos
Main Authors: Piepenbrink, Kurt H., Borbulevych, Oleg Y., Sommese, Ruth F., Clemens, John, Armstrong, Kathryn M., Desmond, Clare, Do, Priscilla, Baker, Brian M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3014826/
https://ncbi.nlm.nih.gov/pubmed/19698083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20090732
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