Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways

More than 2% of adults harbor a pancreatic cyst, a subset of which progresses to invasive lesions with lethal consequences. To assess the genomic landscapes of neoplastic cysts of the pancreas, we determined the exomic sequences of DNA from the neoplastic epithelium of eight surgically resected cyst...

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Detalhes bibliográficos
Main Authors: Wu, Jian, Jiao, Yuchen, Dal Molin, Marco, Maitra, Anirban, de Wilde, Roeland F., Wood, Laura D., Eshleman, James R., Goggins, Michael G., Wolfgang, Christopher L., Canto, Marcia I., Schulick, Richard D., Edil, Barish H., Choti, Michael A., Adsay, Volkan, Klimstra, David S., Offerhaus, G. Johan A., Klein, Alison P., Kopelovich, Levy, Carter, Hannah, Karchin, Rachel, Allen, Peter J., Schmidt, C. Max, Naito, Yoshiki, Diaz, Luis A., Kinzler, Kenneth W., Papadopoulos, Nickolas, Hruban, Ralph H., Vogelstein, Bert
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248495/
https://ncbi.nlm.nih.gov/pubmed/22158988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1118046108
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