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Whole-body deletion of LPS-induced TNF-α factor (LITAF) markedly improves experimental endotoxic shock and inflammatory arthritis

LPS-induced TNF-α factor (LITAF) mediates cytokine expression in response to endotoxin challenge. Previously, we reported that macrophage-specific LITAF-deficient (macLITAF(−/−)) mice exposed to LPS have a delayed onset in the serum levels of proinflammatory cytokines and prolonged persistence of an...

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Autori principali: Merrill, Jamie C., You, Jian, Constable, Cara, Leeman, Susan E., Amar, Salomon
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248491/
https://ncbi.nlm.nih.gov/pubmed/22160695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1111492108
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