Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets

The p53-family member TAp73 is a transcription factor that plays a key role in many biological processes. Here, we show that p73 drives the expression of microRNA (miR)-34a, but not miR-34b and -c, by acting on specific binding sites on the miR-34a promoter. Expression of miR-34a is modulated in par...

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Main Authors: Agostini, Massimiliano, Tucci, Paola, Killick, Richard, Candi, Eleonora, Sayan, Berna S., Rivetti di val Cervo, Pia, Nicotera, Pierluigi, McKeon, Frank, Knight, Richard A., Mak, Tak W., Melino, Gerry
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2011
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248477/
https://ncbi.nlm.nih.gov/pubmed/22160687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1112061109
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