Human adenovirus-specific T cells modulate HIV-specific T cell responses to an Ad5-vectored HIV-1 vaccine

Recombinant viruses hold promise as vectors for vaccines to prevent infectious diseases with significant global health impacts. One of their major limitations is that preexisting anti-vector neutralizing antibodies can reduce T cell responses to the insert antigens; however, the impact of vector-spe...

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Detalhes bibliográficos
Main Authors: Frahm, Nicole, DeCamp, Allan C., Friedrich, David P., Carter, Donald K., Defawe, Olivier D., Kublin, James G., Casimiro, Danilo R., Duerr, Ann, Robertson, Michael N., Buchbinder, Susan P., Huang, Yunda, Spies, Gregory A., Rosa, Stephen C. De, McElrath, M. Juliana
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248307/
https://ncbi.nlm.nih.gov/pubmed/22201684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI60202
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