Obesity is associated with hypothalamic injury in rodents and humans

Rodent models of obesity induced by consuming high-fat diet (HFD) are characterized by inflammation both in peripheral tissues and in hypothalamic areas critical for energy homeostasis. Here we report that unlike inflammation in peripheral tissues, which develops as a consequence of obesity, hypotha...

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Main Authors: Thaler, Joshua P., Yi, Chun-Xia, Schur, Ellen A., Guyenet, Stephan J., Hwang, Bang H., Dietrich, Marcelo O., Zhao, Xiaolin, Sarruf, David A., Izgur, Vitaly, Maravilla, Kenneth R., Nguyen, Hong T., Fischer, Jonathan D., Matsen, Miles E., Wisse, Brent E., Morton, Gregory J., Horvath, Tamas L., Baskin, Denis G., Tschöp, Matthias H., Schwartz, Michael W.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2011
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248304/
https://ncbi.nlm.nih.gov/pubmed/22201683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI59660
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