Obesity is associated with hypothalamic injury in rodents and humans

Rodent models of obesity induced by consuming high-fat diet (HFD) are characterized by inflammation both in peripheral tissues and in hypothalamic areas critical for energy homeostasis. Here we report that unlike inflammation in peripheral tissues, which develops as a consequence of obesity, hypotha...

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Autori principali: Thaler, Joshua P., Yi, Chun-Xia, Schur, Ellen A., Guyenet, Stephan J., Hwang, Bang H., Dietrich, Marcelo O., Zhao, Xiaolin, Sarruf, David A., Izgur, Vitaly, Maravilla, Kenneth R., Nguyen, Hong T., Fischer, Jonathan D., Matsen, Miles E., Wisse, Brent E., Morton, Gregory J., Horvath, Tamas L., Baskin, Denis G., Tschöp, Matthias H., Schwartz, Michael W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248304/
https://ncbi.nlm.nih.gov/pubmed/22201683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI59660
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