Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers

DNA methylation at the 5-position of cytosines (5mC) represents an important epigenetic modification involved in tissue differentiation and is frequently altered in cancer. Recent evidence suggests that 5mC can be converted to 5-hydroxymethylcytosine (5hmC) in an enzymatic process involving members...

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Autors principals: Haffner, Michael C., Chaux, Alcides, Meeker, Alan K., Esopi, David M., Gerber, Jonathan, Pellakuru, Laxmi G., Toubaji, Antoun, Argani, Pedram, Iacobuzio-Donahue, Christine, Nelson, William G., Netto, George J., De Marzo, Angelo M., Yegnasubramanian, Srinivasan
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2011
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248214/
https://ncbi.nlm.nih.gov/pubmed/21896958
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