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Genetic Modifiers of Cardiovascular Phenotype Caused by Elastin Haploinsufficiency Act by Extrinsic Noncomplementation

Elastin haploinsufficiency causes the cardiovascular complications associated with Williams-Beuren syndrome and isolated supravalvular aortic stenosis. Significant variability exists in the vascular pathology in these individuals. Using the Eln(+/−) mouse, we sought to identify the source of this va...

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Autori principali: Kozel, Beth A., Knutsen, Russell H., Ye, Li, Ciliberto, Christopher H., Broekelmann, Thomas J., Mecham, Robert P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248007/
https://ncbi.nlm.nih.gov/pubmed/22049077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.274779
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