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Hypoxia-inducible Factor-1α Protein Negatively Regulates Load-induced Bone Formation
Mechanical loads induce profound anabolic effects in the skeleton, but the molecular mechanisms that transduce such signals are still poorly understood. In this study, we demonstrate that the hypoxia-inducible factor-1α (Hif-1α) is acutely up-regulated in response to exogenous mechanical stimuli sec...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3248005/ https://ncbi.nlm.nih.gov/pubmed/22081627 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.276683 |
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