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Hypoxia-inducible Factor-1α Protein Negatively Regulates Load-induced Bone Formation
Mechanical loads induce profound anabolic effects in the skeleton, but the molecular mechanisms that transduce such signals are still poorly understood. In this study, we demonstrate that the hypoxia-inducible factor-1α (Hif-1α) is acutely up-regulated in response to exogenous mechanical stimuli sec...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3248005/ https://ncbi.nlm.nih.gov/pubmed/22081627 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.276683 |
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