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Thromboxane Receptor Signaling Is Required for Fibronectin-induced Matrix Metalloproteinase 9 Production by Human and Murine Macrophages and Is Attenuated by the Arhgef1 Molecule

During an inflammatory response, resident and newly recruited tissue macrophages adhere to extracellular matrix and cell-bound integrin ligands. This interaction induces the expression of pro-inflammatory mediators that include matrix metalloproteinases (MMPs). Arhgef1 is an intracellular signaling...

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Detalhes bibliográficos
Main Authors: Hartney, John M., Gustafson, Claire E., Bowler, Russell P., Pelanda, Roberta, Torres, Raul M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3247948/
https://ncbi.nlm.nih.gov/pubmed/22086927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.282772
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