Vorinostat increases expression of functional norepinephrine transporter in neuroblastoma in vitro and in vivo model systems

PURPOSE: Histone deacetylase (HDAC) inhibition causes transcriptional activation or repression of several genes that in turn can influence the biodistribution of other chemotherapeutic agents. Here, we hypothesize that the combination of vorinostat, a HDAC inhibitor, with (131)I-metaiodobenzylguanid...

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Detalhes bibliográficos
Main Authors: More, Swati S., Itsara, Melissa, Yang, Xiaodong, Geier, Ethan G., Tadano, Michelle K., Seo, Youngho, VanBrocklin, Henry F., Weiss, William A., Mueller, Sabine, Haas-Kogan, Daphne A., DuBois, Steven G., Matthay, Katherine K., Giacomini, Kathleen M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3247296/
https://ncbi.nlm.nih.gov/pubmed/21421857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-2949
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