Phase I study of vorinostat in combination with isotretinoin in patients with refractory/recurrent neuroblastoma: A new approaches to Neuroblastoma Therapy (NANT) trial

BACKGROUND: Vorinostat combined with retinoids produces additive antitumor effects in preclinical studies of neuroblastoma. Higher systemic exposures of vorinostat than achieved in pediatric phase I trials with continuous daily dosing are necessary for in vivo increased histone acetylation and cytot...

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Bibliographic Details
Published in:Pediatr Blood Cancer
Main Authors: Pinto, Navin, DuBois, Steven G., Marachelian, Araz, Diede, Scott J., Taraseviciute, Agne, Glade Bender, Julia L., Tsao-Wei, Denice, Groshen, Susan G., Reid, Joel M., Haas-Kogan, Daphne A., Reynolds, C. Patrick, Kang, Min H., Irwin, Meredith S., Macy, Margaret E., Villablanca, Judith G., Matthay, Katherine K., Park, Julie R.
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6040651/
https://ncbi.nlm.nih.gov/pubmed/29603591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.27023
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