Grp/DChk1 is required for G(2)-M checkpoint activation in Drosophila S2 cells, whereas Dmnk/DChk2 is dispensable

Cell-cycle checkpoints are signal-transduction pathways required to maintain genomic stability in dividing cells. Previously, it was reported that two kinases essential for checkpoint signalling, Chk1 and Chk2 are structurally conserved. In contrast to yeast, Xenopus and mammals, the Chk1- and Chk2-...

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Bibliographic Details
Main Authors: de Vries, Hilda I., Uyetake, Lyle, Lemstra, Willy, Brunsting, Jeanette F., Su, Tin Tin, Kampinga, Harm H., Sibon, Ody C. M.
Format: Artigo
Language:Inglês
Published: 2005
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3247295/
https://ncbi.nlm.nih.gov/pubmed/15860729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.02309
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