MONODISPERSED PEG-DOTA CONJUGATED ANTI-TAG-72 DIABODY HAS LOW KIDNEY UPTAKE AND HIGH TUMOR TO BLOOD RATIOS RESULTING IN IMPROVED (64)Cu PET IMAGING

Diabodies are non-covalent dimers of single chain antibody fragments (scFvs) that retain the avidity of intact IgG but have more favorable blood clearance than intact IgGs. Radiometals offer a wide range of half lives and emissions for matching imaging and therapy requirements and provide facile lab...

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Main Authors: Li, Lin, Turatti, Fabio, Crow, Desiree, Bading, James R., Anderson, Anne-Line, Poku, Erasmus, Yazaki, Paul J., Williams, Lawrence E., Tamvakis, Debra, Sanders, Paul, Leong, David, Raubitschek, Andrew, Hudson, Peter J., Colcher, David, Shively, John E.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3247072/
https://ncbi.nlm.nih.gov/pubmed/20554731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.109.074153
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