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SITE SPECIFIC CONJUGATION OF MONODISPERSED DOTA-PEGn TO THIOLATED DIABODY REVEALS EFFECT OF INCREASING PEG SIZE ON KIDNEY CLEARANCE AND TUMOR UPTAKE WITH IMPROVED 64-COPPER PET IMAGING

Optimal PET imaging of tumors with radiolabeled engineered antibodies requires, among other parameters, matching blood clearance and tumor uptake with the half-life of the engineered antibody. Although diabodies have favorable molecular sizes (50 kDa) for rapid blood clearance (t(1/2)= 30-60 min) an...

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Main Authors: Li, Lin, Crow, Desiree, Turatti, Fabio, Bading, James R., Anderson, Anne-Line, Poku, Erasmus, Yazaki, Paul J., Carmichael, Jenny, Leong, David, Wheatcroft, Michael P., Raubitschek, Andrew A., Hudson, Peter J., Colcher, David, Shively, John E.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100794/
https://ncbi.nlm.nih.gov/pubmed/21395337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc100464e
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