Aurora A and Aurora B jointly coordinate chromosome segregation and anaphase microtubule dynamics

We established a conditional deletion of Aurora A kinase (AurA) in Cdk1 analogue-sensitive DT40 cells to analyze AurA knockout phenotypes after Cdk1 activation. In the absence of AurA, cells form bipolar spindles but fail to properly align their chromosomes and exit mitosis with segregation errors....

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Bibliografiske detaljer
Main Authors: Hégarat, Nadia, Smith, Ewan, Nayak, Gowri, Takeda, Shunichi, Eyers, Patrick A., Hochegger, Helfrid
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2011
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3246887/
https://ncbi.nlm.nih.gov/pubmed/22184196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201105058
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