Beta-Cell Specific Deletion of Dicer1 Leads to Defective Insulin Secretion and Diabetes Mellitus

Mature microRNAs (miRNAs), derived through cleavage of pre-miRNAs by the Dicer1 enzyme, regulate protein expression in many cell-types including cells in the pancreatic islets of Langerhans. To investigate the importance of miRNAs in mouse insulin secreting β-cells, we have generated mice with a β-c...

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Main Authors: Kalis, Martins, Bolmeson, Caroline, Esguerra, Jonathan L. S., Gupta, Shashank, Edlund, Anna, Tormo-Badia, Neivis, Speidel, Dina, Holmberg, Dan, Mayans, Sofia, Khoo, Nelson K. S., Wendt, Anna, Eliasson, Lena, Cilio, Corrado M.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3246465/
https://ncbi.nlm.nih.gov/pubmed/22216196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029166
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