Novel glycolipids that elicit IFN-γ-biased responses from natural killer T cells

Natural killer T (NKT) cells recognize glycolipids presented by CD1d. The first antigen described, α-galactosyl ceramide (αGalCer), is a potential anti-cancer agent whose activity depends upon IFN-γ secretion. Here we report two analogs of αGalCer based on a naturally occurring glycosphingolipid, pl...

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Hauptverfasser: Tyznik, Aaron J., Farber, Elisa, Girardi, Enrico, Birkholz, Alysia, Li, Yali, Chitale, Sampada, So, Regina, Arora, Pooja, Khurana, Archana, Wang, Jing, Porcelli, Steven A., Zajonc, Dirk M., Kronenberg, Mitchell, Howell, Amy R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3246403/
https://ncbi.nlm.nih.gov/pubmed/22195564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2011.10.015
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