The Vα14 invariant natural killer T cell TCR forces microbial glycolipids and CD1d into a conserved binding mode

Invariant natural killer T cells (iNKT cells) rapidly produce effector cytokines. In this study, we report the first crystal structures of the iNKT cell T cell receptor (TCR) bound to two natural, microbial glycolipids presented by CD1d. Binding of the TCR induced CDR3-α–dependent structural changes...

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Autores principales: Li, Yali, Girardi, Enrico, Wang, Jing, Yu, Esther Dawen, Painter, Gavin F., Kronenberg, Mitchell, Zajonc, Dirk M.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964572/
https://ncbi.nlm.nih.gov/pubmed/20921281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20101335
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