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The Vα14 invariant natural killer T cell TCR forces microbial glycolipids and CD1d into a conserved binding mode
Invariant natural killer T cells (iNKT cells) rapidly produce effector cytokines. In this study, we report the first crystal structures of the iNKT cell T cell receptor (TCR) bound to two natural, microbial glycolipids presented by CD1d. Binding of the TCR induced CDR3-α–dependent structural changes...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The Rockefeller University Press
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2964572/ https://ncbi.nlm.nih.gov/pubmed/20921281 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20101335 |
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