Endolysosomal sorting of ubiquitinated caveolin-1 is regulated by VCP/p97 and UBXD1 and impaired by VCP disease mutations

The AAA-ATPase VCP/p97 cooperates with distinct cofactors to process ubiquitinated proteins in different cellular pathways (1–3). VCP missense mutations cause a systemic degenerative disease in humans, but the molecular pathogenesis is unclear (4, 5). We used an unbiased mass spectrometry approach a...

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Hauptverfasser: Ritz, Danilo, Vuk, Maja, Kirchner, Philipp, Bug, Monika, Schütz, Sabina, Hayer, Arnold, Bremer, Sebastian, Lusk, Caleb, Baloh, Robert H., Lee, Houkeun, Glatter, Timo, Gstaiger, Matthias, Aebersold, Ruedi, Weihl, Conrad C., Meyer, Hemmo
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3246400/
https://ncbi.nlm.nih.gov/pubmed/21822278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2301
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