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A new proofreading mechanism for lesion bypass by DNA polymerase-λ
Replicative DNA polymerases (DNA pols) increase their fidelity by removing misincorporated nucleotides with their 3′ → 5′ exonuclease activity. Exonuclease activity reduces translesion synthesis (TLS) efficiency and TLS DNA pols lack 3′ → 5′ exonuclease activity. Here we show that physiological conc...
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| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group
2012
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3246252/ https://ncbi.nlm.nih.gov/pubmed/22134548 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2011.226 |
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