Clinical Stratification of Glioblastoma Based on Alterations in Retinoblastoma Tumor Suppressor Protein (RB1) and Association with the Proneural Subtype

A recent study of CDK4/6-inhibitors in glioblastoma (GBM) xenografts identified retinoblastoma tumor suppressor protein RB1 status as a determinant of tumor therapeutic efficacy. Because of the need for clinically applicable RB1 testing, we assessed the utility of 2 complementary methods for determi...

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Hlavní autoři: Goldhoff, Patricia, Clarke, Jennifer, Smirnov, Ivan, Berger, Mitchel S., Prados, Michael D., James, C. David, Perry, Arie, Phillips, Joanna J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3246124/
https://ncbi.nlm.nih.gov/pubmed/22157621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/NEN.0b013e31823fe8f1
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