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Wild type and P301L mutant Tau promote neuro-inflammation and α-Synuclein accumulation in lentiviral gene delivery models

Neurodegeneration involves multiple pathogenic proteins, including Tau, Aβ, TDP-43 and α-Synuclein, but there is little information how these pathogenic proteins interact. We cloned human wild type 4 repeat Tau (Tau(wt)) and mutant Tau(P301L) into a lentivirus and performed stereotaxic injection int...

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Bibliografski detalji
Glavni autori: Khandelwal, Preeti J., Dumanis, Sonya B., Herman, Alexander M., Rebeck, G. William, Moussa, Charbel E-H
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3246111/
https://ncbi.nlm.nih.gov/pubmed/21945393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mcn.2011.09.002
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