Toxoplasma gondii HLA-B*0702 restricted GRA7(20–28) peptide with adjuvants and an universal helper T cell epitope elicits CD8(+) T cells producing IFN-γ and reduces parasite burden in HLA-B*0702 mice

Ability of CD8(+) T cells to act as cytolytic effectors and produce IFN-γ was shown to mediate resistance to Toxoplasma gondii in murine models due to recognition of peptides restricted by murine MHC Class I molecules. However, no T. gondii specific HLA-B07 restricted peptides were proven protective...

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Autori principali: Cong, Hua, Mui, Ernest J., Witola, William H., Sidney, John, Alexander, Jeff, Sette, Alessandro, Maewal, Ajesh, El Bissati, Kamal, Zhou, Ying, Suzuki, Yasuhiro, Lee, Daniel, Woods, Stuart, Sommerville, Caroline, Henriquez, Fiona, W.Roberts, Craig, McLeod, Rima
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3246109/
https://ncbi.nlm.nih.gov/pubmed/22027386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.humimm.2011.10.006
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