Human immunome, bioinformatic analyses using HLA supermotifs and the parasite genome, binding assays, studies of human T cell responses, and immunization of HLA-A*1101 transgenic mice including novel adjuvants provide a foundation for HLA-A03 restricted CD8(+)T cell epitope based, adjuvanted vaccine protective against Toxoplasma gondii

BACKGROUND: Toxoplasmosis causes loss of life, cognitive and motor function, and sight. A vaccine is greatly needed to prevent this disease. The purpose of this study was to use an immmunosense approach to develop a foundation for development of vaccines to protect humans with the HLA-A03 supertype....

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Main Authors: Cong, Hua, Mui, Ernest J, Witola, William H, Sidney, John, Alexander, Jeff, Sette, Alessandro, Maewal, Ajesh, McLeod, Rima
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2010
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3009956/
https://ncbi.nlm.nih.gov/pubmed/21129215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1745-7580-6-12
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