Targeted detection of in vivo endogenous DNA base damage reveals preferential base excision repair in the transcribed strand

Endogenous DNA damage is removed mainly via base excision repair (BER), however, whether there is preferential strand repair of endogenous DNA damage is still under intense debate. We developed a highly sensitive primer-anchored DNA damage detection assay (PADDA) to map and quantify in vivo endogeno...

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Библиографические подробности
Главные авторы: Reis, António M. C., Mills, Wilbur K., Ramachandran, Ilangovan, Friedberg, Errol C., Thompson, David, Queimado, Lurdes
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2012
Предметы:
Genome Integrity, Repair and Replication
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3245927/
https://ncbi.nlm.nih.gov/pubmed/21911361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr704
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