Targeted detection of in vivo endogenous DNA base damage reveals preferential base excision repair in the transcribed strand

Endogenous DNA damage is removed mainly via base excision repair (BER), however, whether there is preferential strand repair of endogenous DNA damage is still under intense debate. We developed a highly sensitive primer-anchored DNA damage detection assay (PADDA) to map and quantify in vivo endogeno...

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Detalhes bibliográficos
Principais autores: Reis, António M. C., Mills, Wilbur K., Ramachandran, Ilangovan, Friedberg, Errol C., Thompson, David, Queimado, Lurdes
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3245927/
https://ncbi.nlm.nih.gov/pubmed/21911361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr704
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