Dictyostelium chemotaxis: essential Ras activation and accessory signalling pathways for amplification

Central to chemotaxis is the molecular mechanism by which cells exhibit directed movement in shallow gradients of a chemoattractant. We used Dictyostelium mutants to investigate the minimal requirements for chemotaxis, and identified a basal signalling module providing activation of Ras at the leadi...

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Detalles Bibliográficos
Main Authors: Kortholt, Arjan, Kataria, Rama, Keizer-Gunnink, Ineke, Van Egmond, Wouter N, Khanna, Ankita, Van Haastert, Peter J M
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2011
Assuntos:
Scientific Reports
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3245697/
https://ncbi.nlm.nih.gov/pubmed/22081140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2011.210
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