A phospho-proteomic screen identifies substrates of the checkpoint kinase Chk1

BACKGROUND: The cell-cycle checkpoint kinase Chk1 is essential in mammalian cells due to its roles in controlling processes such as DNA replication, mitosis and DNA-damage responses. Despite its paramount importance, how Chk1 controls these functions remains unclear, mainly because very few Chk1 sub...

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Bibliografiske detaljer
Main Authors: Blasius, Melanie, Forment, Josep V, Thakkar, Neha, Wagner, Sebastian A, Choudhary, Chunaram, Jackson, Stephen P
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2011
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3245618/
https://ncbi.nlm.nih.gov/pubmed/21851590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2011-12-8-r78
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