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Lack of sufficiently strong informative features limits the potential of gene expression analysis as predictive tool for many clinical classification problems

BACKGROUND: Our goal was to examine how various aspects of a gene signature influence the success of developing multi-gene prediction models. We inserted gene signatures into three real data sets by altering the expression level of existing probe sets. We varied the number of probe sets perturbed (s...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Hess, Kenneth R, Wei, Caimiao, Qi, Yuan, Iwamoto, Takayuki, Symmans, W Fraser, Pusztai, Lajos
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: BioMed Central 2011
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3245512/
https://ncbi.nlm.nih.gov/pubmed/22132775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-12-463
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