How do mutations in lamins A and C cause disease?

Mutations in lamins A and C, nuclear intermediate-filament proteins in nearly all somatic cells, cause a variety of diseases that primarily affect striated muscle, adipocytes, or peripheral nerves or cause features of premature aging. Two new studies use lamin A/C–deficient mice, which develop stria...

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Bibliographic Details
Main Authors: Worman, Howard J., Courvalin, Jean-Claude
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2004
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Commentary
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC324546/
https://ncbi.nlm.nih.gov/pubmed/14755330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200420832
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