Site and mechanism of leptin action in a rodent form of congenital lipodystrophy

Lipodystrophy is characterized by the complete or partial absence of adipose tissue, insulin resistance, hepatic steatosis, and leptin deficiency. Here, we show that low-dose central leptin corrects the insulin resistance and fatty liver of lipodystrophic aP2-nSREBP-1c mice, while the same dose give...

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Main Authors: Asilmaz, Esra, Cohen, Paul, Miyazaki, Makoto, Dobrzyn, Pawel, Ueki, Kohjiro, Fayzikhodjaeva, Gulnorakhon, Soukas, Alexander A., Kahn, C. Ronald, Ntambi, James M., Socci, Nicholas D., Friedman, Jeffrey M.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2004
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC324539/
https://ncbi.nlm.nih.gov/pubmed/14755338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200419511
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