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Robust Identification of Binding Hot Spots Using Continuum Electrostatics: Application to Hen Egg-White Lysozyme
[Image: see text] Binding hot spots, protein regions with high binding affinity, can be identified by using X-ray crystallography or NMR spectroscopy to screen libraries of small organic molecules that tend to cluster at such hot spots. FTMap, a direct computational analogue of the experimental scre...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Chemical Society
2011
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| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3244821/ https://ncbi.nlm.nih.gov/pubmed/22092261 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja207914y |
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