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Design, synthesis, and biological evaluation of estrone-derived hedgehog signaling inhibitors¶
The design, synthesis and biological evaluation of new analogs of the naturally occurring compound cyclopamine, a Hedgehog signaling inhibitor, are described. Stucture-activity relationship studies lead to an evolving model for the pharmacophore of this medically promising compound class of anti-can...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3244726/ https://ncbi.nlm.nih.gov/pubmed/22199406 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tet.2011.10.028 |
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