Formation of 1,2:3,4-Diepoxybutane-Specific Hemoglobin Adducts in 1,3-Butadiene Exposed Workers

1,3-Butadiene (BD) is an important industrial chemical that is classified as a human carcinogen. BD carcinogenicity has been attributed to its metabolism to several reactive epoxide metabolites and formation of the highly mutagenic 1,2:3,4-diepoxybutane (DEB) has been hypothesized to drive mutagenes...

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Bibliografiske detaljer
Main Authors: Boysen, Gunnar, Georgieva, Nadia I., Bordeerat, Narisa K., Šram, Radim J., Vacek, Pamela, Albertini, Richard J., Swenberg, James A.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2012
Fag:
Carcinogenicity
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3243749/
https://ncbi.nlm.nih.gov/pubmed/22003190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfr272
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