Amiodarone Exposure During Modest Inflammation Induces Idiosyncrasy-like Liver Injury in Rats: Role of Tumor Necrosis Factor-alpha

Amiodarone [2-butyl-3-(3′,5′-diiodo-4’α-diethylaminoethoxybenzoyl)-benzofuran] (AMD), a class III antiarrhythmic drug, is known to cause idiosyncratic hepatotoxic reactions in human patients. One hypothesis for the etiology of idiosyncratic adverse drug reactions is that a concurrent inflammatory st...

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Main Authors: Lu, Jingtao, Jones, A. Daniel, Harkema, Jack R., Roth, Robert A., Ganey, Patricia E.
格式: Artigo
語言:Inglês
出版: Oxford University Press 2012
主題:
Immunotoxicology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3243747/
https://ncbi.nlm.nih.gov/pubmed/21984482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfr266
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