Pyrimidine-specific chemical reactions useful for DNA sequencing.

Potassium permanganate reacts selectively with thymidine residues in DNA (1) while hydroxylamine hydrochloride at pH 6 specifically attacks cytosine (2). We have adopted these reactions for use with the chemical sequencing method developed by Maxam and Gilbert (3).

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Bibliografiske detaljer
Main Authors: Rubin, C M, Schmid, C W
Format: Artigo
Sprog:Inglês
Udgivet: 1980
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC324374/
https://ncbi.nlm.nih.gov/pubmed/7443522
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