E3 Ligases Determine Ubiquitination Site and Conjugate Type by Enforcing Specificity on E2 Enzymes

Ubiquitin-conjugating enzymes (E2s) have a dominant role in determining which of the seven lysine residues of ubiquitin is used for polyubiquitination. Here we show that tethering of a substrate to an E2 enzyme in the absence of an E3 ubiquitin ligase is sufficient to promote its ubiquitination, whe...

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Bibliografiske detaljer
Main Authors: David, Yael, Ternette, Nicola, Edelmann, Mariola J., Ziv, Tamar, Gayer, Batya, Sertchook, Rotem, Dadon, Yakir, Kessler, Benedikt M., Navon, Ami
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Protein Synthesis and Degradation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3243545/
https://ncbi.nlm.nih.gov/pubmed/21965653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.234559
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