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Tie2-dependent knockout of HIF-1 impairs burn wound vascularization and homing of bone marrow-derived angiogenic cells
AIMS: Hypoxia-inducible factor 1 (HIF-1) is a heterodimer composed of HIF-1α and HIF-1β subunits. HIF-1 is known to promote tissue vascularization by activating the transcription of genes encoding angiogenic factors, which bind to receptors on endothelial cells (ECs) and bone marrow-derived angiogen...
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Main Authors: | , , , , , , , , , , , , , |
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Format: | Artigo |
Jezik: | Inglês |
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Oxford University Press
2012
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Teme: | |
Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3243042/ https://ncbi.nlm.nih.gov/pubmed/22028336 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvr282 |
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