Tie2-dependent knockout of HIF-1 impairs burn wound vascularization and homing of bone marrow-derived angiogenic cells

AIMS: Hypoxia-inducible factor 1 (HIF-1) is a heterodimer composed of HIF-1α and HIF-1β subunits. HIF-1 is known to promote tissue vascularization by activating the transcription of genes encoding angiogenic factors, which bind to receptors on endothelial cells (ECs) and bone marrow-derived angiogen...

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Autores principales: Sarkar, Kakali, Rey, Sergio, Zhang, Xianjie, Sebastian, Raul, Marti, Guy P., Fox-Talbot, Karen, Cardona, Amanda V., Du, Junkai, Tan, Yee Sun, Liu, Lixin, Lay, Frank, Gonzalez, Frank J., Harmon, John W., Semenza, Gregg L.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2012
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3243042/
https://ncbi.nlm.nih.gov/pubmed/22028336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvr282
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