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Age-dependent Impairment of HIF-1α̣Expression in Diabetic Mice: Correction with Electroporation-facilitated Gene Therapy Increases Wound Healing, Angiogenesis, and Circulating Angiogenic Cells

Wound healing is impaired in elderly patients with diabetes mellitus. We hypothesized that age-dependent impairment of cutaneous wound healing in db/db diabetic mice: (a) would correlate with reduced expression of the transcription factor hypoxia-inducible factor 1α (HIF-1α) as well as its downstrea...

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Bibliografske podrobnosti
Main Authors: Liu, Lixin, Marti, Guy P., Wei, Xiaofei, Zhang, Xianjie, Zhang, Huafeng, Liu, Ye V., Nastai, Manuel, Semenza, Gregg L., Harmon, John W.
Format: Artigo
Jezik:Inglês
Izdano: 2008
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2716010/
https://ncbi.nlm.nih.gov/pubmed/18506785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.21503
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